Tubulin and Microtubules as Drug Targets for Potential Cancer Chemotherapy and CNS-Directed Therapies

SKU: 9788893772426
AnnoPubblicazione: 
2022
Collana: 
Studi e Ricerche
Numero Collana: 
118
Collezione: 
Scienze e Tecnologie
formato: 
16x23
pagine: 
348
lingua: 
inglese
tipologia: 
monografia
formato elettronico: 
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Work published in open access form and licensed under Creative Commons Attribution – NonCommercial – NoDerivatives 3.0 Italy (CC BY-NC-ND 3.0 IT).
Opera distribuita con licenza Creative Commons Attribuzione – Non commerciale – Non opere derivate 3.0 Italia e diffusa in modalità open access (CC BY-NC-ND 3.0 IT).

Winner of the Competition “Prize for PhD Thesis 2020” arranged by Sapienza University Press.

Microtubules are essential cellular constituents of eukaryotes formed by tubulin subunits. This book is a collection of medicinal chemistry research projects that utilizes microtubules as drug targets for human diseases of global health impact. The main chapters (2 – 4) include an in-depth description of different synthetic and biological approaches to characterize the therapeutic potential of novel synthetic molecules for cancer, Alzheimer’s disease, and neglected tropical diseases. This book also includes three short chapters (5 – 7) of additional collaborative projects focused on varied drug discovery topics, including SAR studies of new lead compounds targeting carbonic anhydrase enzymes, FAAH and TRPV1, and novel bioisosteres of the carboxylic acid functional group.

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DOI: 
https://doi.org/10.13133/9788893772426

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